Impact of Orthoclone OKT3 on liver transplantation.
نویسندگان
چکیده
منابع مشابه
ORTHOCLONE OKT3 in Treatment of Allografts Rejected Under Cyclosporine-Steroid Therapy.
I N 1899, Metchnikoff first conceived of specific therapy with antilymphocyte globulin (ALG) compounds.! Research was carried out sporadically in Europe, mostly by Swiss immunologists. Antilymphocyte serum (ALS) was first used to prevent skin graft rejection in experimental animals by Waksman et al2 and subsequently by Woodruff and Anderson.3 ALG was first used clinically in 1966.4 Its value wa...
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M URINE MONOCLONAL antibody OKTJ (orthoclone OKT3). is a powerful immunosuppressant and has been shown to be very effective in reversal of acute rejection following kidney, liver a nd heart transplants. I·) As with any kind of immunosuppression, one would expect that use of OKTJ might be associated with increased incidence of infections. However, there have been only a few detailed studies of i...
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Th1 derived cytokines IFN-gamma and IL-2, Th2 cytokine IL-4, and ICAM-1 have been implicated in liver allograft rejection. In order to determine whether monitoring of cytokine profiles during the first days post-liver transplant can predict early rejection we measured IFN-gg, IL-2, sIL-2 receptor, IL-4 and ICAM-1 in 22 patients, in plasma samples obtained within 4 h after liver perfusion (basel...
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Thirty-six ciclosporin-prednisone-treated recipients of nonmatched cadaver renal allografts were given a course of Orthoclone OKT3 monoclonal antibody for steroid-resistant cell-mediated rejection. Although side effects were common, only 2 patients had to be withdrawn from therapy and there were no deaths related to therapy. Twenty-three (63.9%) allografts were rescued with OKT3 therapy and 21 ...
متن کاملRenal-sparing immunosuppressive protocol using OKT3 after liver transplantation: a 19-year single-institution experience.
Different renal-sparing immunosuppressive protocols have been used in liver transplantation. At our institution, muromonab-CD3 (OKT3) is used in patients with acute renal failure (ARF), along with a delay in starting a calcineurin inhibitor. This study was conducted to compare outcomes in liver transplant patients with ARF who received OKT3 and those who did not. From 1988 to 2007, ARF was pres...
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عنوان ژورنال:
- Transplantation proceedings
دوره 19 2 Suppl 1 شماره
صفحات -
تاریخ انتشار 1987